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As the pH changes, the proportion of ionized to nonionized drug will change according to the Henderson-Hasselbach equations: Whereas the precise ratios of ionized versus nonionized drug can be calculated from the Henderson-Hasselbach equations, the relevance of the equations can be understood by simply remembering the sentence like is nonionized in like. For example, a weak acid will be most nonionized in an acidic environment, so aspirin is most nonionized in the stomach and is readily absorbed

Hypertriglyceridemia and hyperinsulinemia are potent inducers of endothelin-1 release in humans

These factors are thought to be important for the pathogenesis of diabetic neuropathy

Bcl-2/Bax ratio increased

Curcumin has emerged as a promising candidate due to its potent anti-inflammatory and antioxidant properties (546)

To date, we have identified 25 genetically encoded selenoproteins in human, including glutathione peroxidase (GPx), thioredoxin reductase (TXNRD), and iodothyronine deiodinases (DIOs), which have a wide range of functions, from anti-inflammatory and antioxidant activities to thyroid hormone metabolism